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Ionis Pharmaceuticals, Inc. (IONS)
72.45  2.91 (4.18%)    11-11 16:00
Open: 69.04
High: 72.79
Volume: 2,132,864
  
Pre. Close: 69.54
Low: 68.55
Market Cap: 11,513(M)
Technical analysis
2025-11-11 4:47:41 PM
Short term     
Mid term     
Targets 6-month :  89.67 1-year :  104.74
Resists First :  76.77 Second :  89.67
Pivot price 72.77
Supports First :  70.52 Second :  66.66
MAs MA(5) :  72.86 MA(20) :  72.76
MA(100) :  55.09 MA(250) :  41.96
MACD MACD :  1.5 Signal :  2.2
%K %D K(14,3) :  45.4 D(3) :  52.1
RSI RSI(14): 54.8
52-week High :  76.77 Low :  23.95
Price, MAs and Bollinger Bands

Price has closed below its short-term moving average. Short-term moving average is currently above mid-term; and above long-term moving average. From the relationship between price and moving averages: This stock is NEUTRAL in short-term; and BULLISH in mid-long term.
[ IONS ] has closed above bottom band by 44.3%. Bollinger Bands are 38.8% narrower than normal. The current width of the bands does not suggest anything about the future direction or movement of prices.

Stock Price Prediction
If tomorrow: Open lower Open higher
High: 72.82 - 73.26 73.26 - 73.69
Low: 67.55 - 68.05 68.05 - 68.52
Close: 71.65 - 72.42 72.42 - 73.15
Company Description

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of TTR amyloidosis; Olezarsen for patients with severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Tofersen to inhibit the production of superoxide dismutase 1. In addition, the company develops medicines for metabolic diseases, infectious diseases, renal diseases, ophthalmic diseases, and cancer. It has a strategic collaboration with Biogen Inc.; and collaboration and license agreement with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc. Ionis Pharmaceuticals, Inc. was founded in 1989 and is based in Carlsbad, California.

Headline News

Tue, 11 Nov 2025
Ionis Announces Proposed Convertible Offering To Refinance 2026 Convertible Notes - TradingView

Tue, 11 Nov 2025
Ionis (NASDAQ: IONS) plans $700M convertible notes to refinance 2026 debt - Stock Titan

Tue, 11 Nov 2025
Ionis Announces Proposed Convertible Offering to Refinance 2026 Convertible Notes - Yahoo Finance

Mon, 10 Nov 2025
HC Wainwright & Co. Maintains Ionis Pharmaceuticals (IONS) Buy Recommendation - Nasdaq

Mon, 10 Nov 2025
Ionis: Near-Term Launches With Blockbuster Potential Boosts Upside Despite Stock Rally - Seeking Alpha

Mon, 10 Nov 2025
Ionis Reports Substantial Drop In Acute Pancreatitis Events With Cholesterol Lowering Drug - Benzinga

Financial Analysis
Price to Book Value:
P/BV, a ratio used to compare book value to its current market price, to gauge whether a stock is valued properly.
Underperform
Price to Earnings:
PE, the ratio for valuing a company that measures its current share price relative to its earnings per share (EPS).
Underperform
Discounted cash flow:
DCF, a valuation method used to estimate the value of an investment based on its expected future cash flows.
Underperform
Return on Assets:
ROA, indicates how profitable a company is in relation to its total assets, how efficiently uses assets to generate a profit.
Underperform
Return on Equity:
ROE, a measure of financial performance calculated by dividing net income by equity. a gauge of profitability and efficiency.
Underperform
Debt to Equity:
evaluate financial leverage, reflects the ability of equity to cover outstanding debts in the event of a business downturn.
Underperform
Stock Basics & Statistics
Exchange:
NASDAQ
Sector:
Healthcare
Industry:
Biotechnology
Shares Out 159 (M)
Shares Float 158 (M)
Held by Insiders 0.6 (%)
Held by Institutions 108.6 (%)
Shares Short 13,700 (K)
Shares Short P.Month 11,970 (K)
Stock Financials
EPS -1.76
EPS Est Next Qtrly 0
EPS Est This Year 0
EPS Est Next Year 0
Book Value (p.s.) 3.97
Profit Margin -28.5 %
Operating Margin 30.9 %
Return on Assets (ttm) -5.9 %
Return on Equity (ttm) -60 %
Qtrly Rev. Growth 100.6 %
Gross Profit (p.s.) 0.31
Sales Per Share 5.92
EBITDA (p.s.) -1.61
Qtrly Earnings Growth 0 %
Operating Cash Flow -231 (M)
Levered Free Cash Flow -169 (M)
Stock Valuations
PE Ratio -41.17
PEG Ratio 0
Price to Book value 18.24
Price to Sales 12.23
Price to Cash Flow -50.09
Stock Dividends
Dividend 0
Forward Dividend 0
Dividend Yield 0%
Dividend Pay Date Invalid DateTime.
Ex-Dividend Date Invalid DateTime.

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