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Ionis Pharmaceuticals, Inc. (IONS)
54.93  -1.82 (-3.21%)    07-14 16:00
Open: 55.9
High: 56.455
Volume: 4,700,248
  
Pre. Close: 56.75
Low: 54.5325
Market Cap: 9,078(M)
Technical analysis
2026-07-14 4:45:00 PM
Short term     
Mid term     
Targets 6-month :  86.94 1-year :  101.31
Resists First :  74.43 Second :  86.73
Pivot price 74.74
Supports First :  54.52 Second :  45.36
MAs MA(5) :  63.73 MA(20) :  74.62
MA(100) :  75.18 MA(250) :  70.6
MACD MACD :  -3.5 Signal :  -0.5
%K %D K(14,3) :  1.1 D(3) :  10.1
RSI RSI(14): 24.2
52-week High :  86.73 Low :  40.02
Price, MAs and Bollinger Bands

Price has closed below its short-term moving average. Short-term moving average is currently below mid-term; and below long-term moving average. From the relationship between price and moving averages: This stock is BEARISH in short-term; and BEARISH in mid-long term.
[ IONS ] has closed above bottom band by 1.8%. Bollinger Bands are 401.6% wider than normal. The large width of the bands suggest high volatility as compared to its normal range. The bands have been in this wide range for 10 days. This is a sign that the current trend might continue.

Stock Price Prediction
If tomorrow: Open lower Open higher
High: 56.82 - 57.37 57.37 - 57.7
Low: 53.38 - 54.09 54.09 - 54.52
Close: 54.12 - 55.27 55.27 - 55.96
Company Description

Founded in 1989 and headquartered in Carlsbad, California, Ionis Pharmaceuticals, Inc. is a biopharmaceutical company specializing in the discovery and development of RNA-targeted therapies within the United States. Its commercial portfolio includes three key medications: SPINRAZA, prescribed for spinal muscular atrophy (SMA) in both children and adults; TEGSEDI, an injectable treatment targeting polyneuropathy associated with hereditary transthyretin-mediated amyloidosis in adult patients; and WAYLIVRA, which addresses familial chylomicronemia syndrome and familial partial lipodystrophy. Ionis also maintains a robust pipeline, with several drug candidates currently in Phase 3 clinical trials. These include Eplontersen, a monthly self-administered subcutaneous injection designed for all forms of TTR amyloidosis; Olezarsen, intended for individuals with severe hypertriglyceridemia (SHTG); Donidalorsen, for patients suffering from hereditary angioedema; ION363, aimed at amyotrophic lateral sclerosis (ALS); Pelacarsen, developed for those with established cardiovascular disease and elevated lipoprotein(a); and Tofersen, which works by inhibiting the production of superoxide dismutase 1. Beyond these late-stage assets, the company is actively researching treatments for metabolic, infectious, renal, and ophthalmic diseases, as well as various types of cancer. The firm engages in significant collaborations, notably a strategic partnership with Biogen Inc. Additionally, it holds licensing and collaboration agreements with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc.

Headline News

Tue, 14 Jul 2026
Pomerantz Law Firm Investigates Claims On Behalf of Investors of Ionis Pharmaceuticals, Inc. - IONS | FinancialContent - FinancialContent

Tue, 14 Jul 2026
Ionis Pharmaceuticals, Inc. (IONS) Faces Investor Scrutiny After Surprise Trial Failure Drives Stock Down 23% – HBSS - GlobeNewswire

Tue, 14 Jul 2026
Biogen drops after additional mid-stage trial data for Ionis-partnered Alzheimer’s drug - Seeking Alpha

Tue, 14 Jul 2026
Ionis Begins Dosing in Phase I/II Dravet Syndrome Study - Yahoo Finance

Tue, 14 Jul 2026
An investigational Alzheimer’s drug shows 50% slower decline on a cognition measure - Stock Titan

Fri, 10 Jul 2026
Ionis Pharmaceuticals (IONS) Status Update Summary - Quartr

Financial Analysis
Price to Book Value:
P/BV, a ratio used to compare book value to its current market price, to gauge whether a stock is valued properly.
Underperform
Price to Earnings:
PE, the ratio for valuing a company that measures its current share price relative to its earnings per share (EPS).
Underperform
Discounted cash flow:
DCF, a valuation method used to estimate the value of an investment based on its expected future cash flows.
Underperform
Return on Assets:
ROA, indicates how profitable a company is in relation to its total assets, how efficiently uses assets to generate a profit.
Underperform
Return on Equity:
ROE, a measure of financial performance calculated by dividing net income by equity. a gauge of profitability and efficiency.
Underperform
Debt to Equity:
evaluate financial leverage, reflects the ability of equity to cover outstanding debts in the event of a business downturn.
Underperform
Stock Basics & Statistics
Exchange:
NASDAQ
Sector:
Healthcare
Industry:
Biotechnology
Shares Out 165 (M)
Shares Float 164 (M)
Held by Insiders 0.6 (%)
Held by Institutions 107.2 (%)
Shares Short 17,430 (K)
Shares Short P.Month 16,990 (K)
Stock Financials
EPS -2.01
EPS Est Next Qtrly 0
EPS Est This Year 0
EPS Est Next Year 0
Book Value (p.s.) 2.96
Profit Margin -30.9 %
Operating Margin -47.8 %
Return on Assets (ttm) -7.1 %
Return on Equity (ttm) -67.7 %
Qtrly Rev. Growth 87 %
Gross Profit (p.s.) 0.7
Sales Per Share 6.41
EBITDA (p.s.) -2.05
Qtrly Earnings Growth 0 %
Operating Cash Flow -911 (M)
Levered Free Cash Flow -808 (M)
Stock Valuations
PE Ratio -27.33
PEG Ratio 27.3
Price to Book value 18.55
Price to Sales 8.56
Price to Cash Flow -9.97
Stock Dividends
Dividend 0
Forward Dividend 0
Dividend Yield 0%
Dividend Pay Date Invalid DateTime.
Ex-Dividend Date Invalid DateTime.

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