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Spero Therapeutics, Inc. (SPRO)
1.11  -0.06 (-5.13%)    10-29 16:00
Open: 1.16
High: 1.165
Volume: 209,416
  
Pre. Close: 1.17
Low: 1.11
Market Cap: 65(M)
Technical analysis
2026-10-29 4:47:42 PM
Short term     
Mid term     
Targets 6-month :  1.41 1-year :  1.53
Resists First :  1.21 Second :  1.3
Pivot price 1.14
Supports First :  1.04 Second :  0.87
MAs MA(5) :  1.12 MA(20) :  1.14
MA(100) :  1.47 MA(250) :  2.06
MACD MACD :  -0.1 Signal :  -0.1
%K %D K(14,3) :  47.3 D(3) :  36
RSI RSI(14): 45.1
52-week High :  3.07 Low :  1.04
Price, MAs and Bollinger Bands

Price has closed below its short-term moving average. Short-term moving average is currently below mid-term; and below long-term moving average. From the relationship between price and moving averages: This stock is BEARISH in short-term; and BEARISH in mid-long term.
[ SPRO ] has closed above bottom band by 29.9%. Bollinger Bands are 67.1% narrower than normal. The narrow width of the bands suggests low volatility as compared to its normal range. The bands have been in this narrow range for 58 bars. This is a sign that the market may be about to initiate a new trend.

Stock Price Prediction
If tomorrow: Open lower Open higher
High: 1.17 - 1.17 1.17 - 1.18
Low: 1.1 - 1.1 1.1 - 1.11
Close: 1.1 - 1.11 1.11 - 1.12
Company Description

Spero Therapeutics, Inc. is a biopharmaceutical firm in the clinical development stage, primarily focused on discovering, advancing, and commercializing innovative treatments for multi-drug resistant (MDR) bacterial infections and rare diseases within the United States. The company's pipeline includes several key therapeutic candidates: tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic designed to address complicated urinary tract infections (cUTIs), including pyelonephritis, in adult patients. SPR206, an intravenously administered agent specifically developed to combat MDR Gram-negative bacterial infections in hospital environments. SPR720, an oral antibiotic targeting non-tuberculous mycobacterial (NTM) pulmonary disease. Spero Therapeutics has also forged several strategic alliances: A licensing agreement with Meiji Seika Pharma Co., Ltd. supports the ongoing development of tebipenem HBr. A separate licensing deal with Everest Medicines grants rights for the development, manufacturing, and commercialization of SPR206 across Greater China, South Korea, and various Southeast Asian nations. The company collaborates with the Bill & Melinda Gates Medical Research Institute to advance SPR720 for treating lung infections caused by Mycobacterium tuberculosis. Furthermore, a licensing agreement with Vertex Pharmaceuticals Incorporated covers patents associated with SPR720 and its active metabolite, SPR719. Founded in 2013, Spero Therapeutics maintains its corporate headquarters in Cambridge, Massachusetts.

Headline News

Wed, 28 Oct 2026
This Spero Therapeutics Analyst Begins Coverage On A Bullish Note; Here Are Top 5 Initiations For Wednesday - Benzinga

Tue, 27 Oct 2026
Spero Therapeutics COO Timothy Keutzer to Retire, Provide Transition Advisory Services - TradingView

Tue, 27 Oct 2026
Spero Therapeutics, Inc. (SPRO) Stock Price, News, Quote & History - Yahoo! Finance Canada

Mon, 26 Oct 2026
Spero Therapeutics (NASDAQ:SPRO) Adds Two Leaders as SP001 Development Advances - Kalkine

Mon, 26 Oct 2026
After 11 years, Spero’s COO is set to retire as two executives take new posts. - Stock Titan

Fri, 23 Oct 2026
Spero Therapeutics, Inc. Estimates – NASDAQ:SPRO - TradingView

Financial Analysis
Price to Book Value:
P/BV, a ratio used to compare book value to its current market price, to gauge whether a stock is valued properly.
Underperform
Price to Earnings:
PE, the ratio for valuing a company that measures its current share price relative to its earnings per share (EPS).
Neutral
Discounted cash flow:
DCF, a valuation method used to estimate the value of an investment based on its expected future cash flows.
Underperform
Return on Assets:
ROA, indicates how profitable a company is in relation to its total assets, how efficiently uses assets to generate a profit.
Outperform
Return on Equity:
ROE, a measure of financial performance calculated by dividing net income by equity. a gauge of profitability and efficiency.
Outperform
Debt to Equity:
evaluate financial leverage, reflects the ability of equity to cover outstanding debts in the event of a business downturn.
Outperform
Stock Basics & Statistics
Exchange:
NASDAQ
Sector:
Healthcare
Industry:
Biotechnology
Shares Out 58 (M)
Shares Float 47 (M)
Held by Insiders 22.6 (%)
Held by Institutions 18.3 (%)
Shares Short 795 (K)
Shares Short P.Month 1,210 (K)
Stock Financials
EPS 0.14
EPS Est Next Qtrly 0
EPS Est This Year 0
EPS Est Next Year 0
Book Value (p.s.) 0.75
Profit Margin 15.7 %
Operating Margin 14 %
Return on Assets (ttm) 7.1 %
Return on Equity (ttm) 19.1 %
Qtrly Rev. Growth 0 %
Gross Profit (p.s.) 0.45
Sales Per Share 0.8
EBITDA (p.s.) 0
Qtrly Earnings Growth 0 %
Operating Cash Flow 20 (M)
Levered Free Cash Flow 29 (M)
Stock Valuations
PE Ratio 7.92
PEG Ratio 0
Price to Book value 1.46
Price to Sales 1.37
Price to Cash Flow 3.3
Stock Dividends
Dividend 0
Forward Dividend 0
Dividend Yield 0%
Dividend Pay Date Invalid DateTime.
Ex-Dividend Date Invalid DateTime.

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